Skin cancer - what general dental practitioners should look for

General dental practitioners (GDPs) are well-placed to identify incidental skin lesions when they see patients for routine dental care. Indeed, some patients with an undiagnosed skin malignancy may only see their GDP on a regular basis rather than their general medical practitioner (GMP). GDPs should be able to assess exposed areas of skin, particularly focusing on the head and neck, to identify any lesions of concern and liaise with the patient's GMP where appropriate. We provide an overview focused upon the clinical appearances of isolated benign and malignant lesions, tailored for GDPs.


Introduction
Skin cancers, comprising basal cell carcinoma (BCC), squamous cell carcinoma (SCC) and melanoma, are the most common of all malignancies. 1Many skin cancers arise due to ultraviolet (UV) radiation, with the face being the highest incidence site in one study. 2Few health care professionals get as close to the head and neck as general dental practitioners (GDPs), and for some, dental check-ups may be their only regular contact with health professionals. 3This presents an opportunity to identify possible skin cancers and refer accordingly, potentially expediting treatment where patients may otherwise delay seeking help until the lesion becomes symptomatic.
This article outlines how to assess and describe skin lesions, then gives an overview of common lesions, under the categories of pigmented and non-pigmented, aiming for familiarity with the common types for a GDP readership, rather than a comprehensive review.We also suggest how to refer lesions from the dental setting in the context of the UK health care setting.

History of skin lesions
History helps to establish the likelihood that a suspicious skin finding is malignant.Onset and rate of growth are important, although patients may not be able to comment on this, particularly if the lesion is on the back of the head.Symptoms of pain (or tenderness to touch), bleeding and itching should be elicited if not volunteered, as they suggest a growing, invasive or irritated lesion. 4isk factors for skin cancer include personal or family history of skin cancer, history of UV exposure, immunosuppression and the skin phototype (Fitzpatrick type).UV exposure is the main risk factor for skin cancer and is usually inferred from occupational and social history. 5Outdoor work (for example, farming, construction) and leisure behaviours (sunbathing, outdoor sports and activities) are relevant, as is having lived in a sunny country.Sunbed use should be asked about.Prior episodes of sunburn, particularly in childhood, are known to increase risk. 6ven apparently low-risk individuals with excellent sun protection habits can still develop skin cancers and sometimes history is not available or forthcoming, so an awareness of what benign lesions and skin cancers look like is also important. 7

Describing skin lesions
Lesions should be assessed in good light with the full extent of the affected skin visible and palpated for texture, tenderness, consistency and mobility.If feasible, photograph the lesion -the patient may be able to do so on their own mobile device, for later presentation to their general medical practitioner (GMP).
Providing a description is helpful when documenting and making a referral as it provides correlation if photographs are unavailable or the patient is unable to later identify the lesion.Site, size and laterality should be specified.Lesion morphology uses specific terminology: flat; impalpable skin changes (for example, freckles or a bruise) are macules if less than 5 mm or patches if larger than this.Palpable lesions are papules if under 5 mm across, nodules if larger and raised, or plaques if larger but flat-topped. 8,9urther description includes colour and surface characteristics.Pigment, if present, can give rise to brown, black and blue coloration.Note any colour variation within the lesion, for example, multiple shades of brown, loss of pigment and asymmetry.Is there erythema (redness that blanches to touch) and telangiectasia (prominent vessels)?These vascular features are more visible in white skin, sometimes appearing purple or brown in skin of colour.Surface changes can include scale (loose or adherent keratin) and crusting (yellow-brown clot or exudate, indicating underlying erosion or ulceration).Also note any widespread changes beyond the lesion, such as inflammation. 8

Pigmented lesions
Pigment derives from melanin, produced by melanocytes and transported to keratinocytes.Increased pigmentation arises physiologically from increased melanin production with stable melanocyte numbers, but change due to melanocyte proliferation is pathological.Physiological causes include facultative pigmentation (tanning) and ephelides (freckles), which are common on sun-exposed sites, especially in children with red hair.These fade in winter, unlike a solar lentigo, which persists, denoting sun damage. 10igmented lesions are broadly divided into melanocytic or non-melanocytic. 11elanocytic lesions arise from melanocyte overgrowth.Naevi (moles) are benign and are categorised as congenital if present at birth or acquired if manifesting afterwards (usually childhood or young adulthood).The depth of the naevus determines its form -intradermal naevi occur within the dermis; junctional naevi arise at the dermo-epidermal junction.Naevi located deep within the dermis appear blueblack and are termed blue naevi.Facial naevi typically begin as flat and brown in childhood, becoming raised and fleshcoloured in adulthood; it is unlikely that a new melanocytic lesion appearing after the age of 40 is harmless. 12enign naevi are typically single-colour, round, well-demarcated and are similarlooking in the same individual.Naevi that deviate from this form are termed atypical naevi, and on histology, may be found to be dysplastic.They are still classed as benign but have an increased potential to become a malignant melanoma (MM). 13M more often arise de novo than develop from existing moles. 14The risk of having a melanoma rises steadily from the age of 20 to 60 when the incidence is around 90 per 100,000 population in the UK, increasing thereafter rapidly with over 25% of new cases diagnosed in people aged 75 and over. 14M has the potential to spread to other skin sites, lymph nodes, lung, bone and the central nervous system.Immunotherapy for advanced melanoma has improved survival rates over recent decades, but the optimal treatment remains early detection and surgical excision. 15 in situ form of melanoma often seen on the face is lentigo maligna.On breaching the dermis, this becomes lentigo maligna melanoma -the risk of it doing so is 5% per year. 16As such, lesions suspicious for lentigo maligna warrant referral and consideration of removal.MM can also present in an amelanotic form with no pigment.Their appearance, of a pale or pink plaque or  Major features (scoring two points each) Minor features (scoring one point each) • Change in size • Irregular shape • Irregular colour.
• Largest diameter 7 mm or more Table 2 Weighted seven-point checklist, from National Institute for Health and Care Excellence guidance.A score of three or more is stated to warrant referral for suspected skin cancer 25,26 nodule, often with vascular markings, may lead to assessment as possible basal or SCC. 4 The features of MM are asymmetry, irregularity of border and chaotic distribution of colour, as typified by Figure 1.The ABCDE (asymmetry, border, colour, diameter, evolving) criteria (Table 1) reflect this. 13A validated riskstratification tool is the seven-point weighted screen (see Table 2), which also includes the late features of ulceration and altered sensation.Both serve as an aide-mémoire for concerning features when assessing a pigmented lesion.Another useful feature in identifying MM is the 'ugly duckling' sign -they look different to the patient's other naevi.

Seborrhoeic keratosis
Seborrhoeic keratosis (SK) is a common benign keratinocyte tumour, illustrated in Figure 2. Around 90% of adults aged over 60 will have at least one SK, which usually start appearing at age 30-40.They can be pigmented, asymmetrical, and if traumatised, can itch, bleed and change appearance due to inflammation.These will thus score on some aspect of ABCDE and raise suspicion of melanoma. 17In their typical form, they have a well-demarcated, plaque-like profile (appearing 'stuck-on').They are rarely solitary and have similar appearance to other ones on the same individual. 18A variant of SK seen in darker skin types is dermatosis papulosa nigra, seen as 1-5 mm multiple brown or dark brown papules on the face, neck and trunk.Onset is in puberty and lesions increase over time.There is a 10-30% prevalence in the Black population. 19

Non-pigmented lesions
The majority of skin cancers are non-melanoma and derive instead from keratinocytes.These cells begin in the basal layer of the epidermis, differentiating into their squamous form with keratin-production as they rise towards the skin surface, ending up as flattened, anuclear corneocytes on the outer layer of the epidermis.Dysplastic and malignant keratinocytes can cease keratin production, making them weak and prone to ulcerate, and increase keratin production resulting in scale or even hornlike projections.In less pigmented skin, UV exposure is the causative agent, with sunexposed sites favoured -photodamage in these areas is evident in the form of wrinkles, solar lentigo and actinic keratosis.

Red scaly marks
Actinic keratosis (AK) is photo-induced squamous cell dysplasia, typically presenting as red, scaly patches (Fig. 3).Keratinous scale is often seen, sometimes resembling horns (hypertrophic AK).These lesions are often found in white, older patients and have a chance of malignant transformation to SCC, so treatment, with cryotherapy, topical chemotherapy or topical anti-inflammatories, is often recommended.Increased thickness, ulceration and pain are suggestive of SCC.
Of particular interest to the GDP is actinic cheilitis (AC) -AK of the lip -which is associated with the same risk factors but a higher risk of malignant progression. 20It has been reported that up to 16.9% of AC may progress to SCC.Moreover, the metastasis rate is four times higher for lip SCCs than those elsewhere. 21The lower lip is favoured due to increased light exposure.GDPs will have direct vision of the lips and should always be vigilant for atrophy, erythema and scaling, either in a localised or diffuse distribution.

Pearly, ulcerated or crusted nodules
Current data estimates one in five people will develop a form of keratinocyte cancer -the term encompassing BCC (Fig. 4) and SCC (Fig. 5)in their lifetime in England.There is a higher risk for men than women. 22BCC and SCC are very uncommon in the under 40s, unless there CLINICAL is a genetic predisposition, such as in Gorlin syndrome, or significant immunosuppression, such as in organ transplant recipients.The incidence rises after 40, with the median age of first incidence reported as 71 years for BCC and 79 for cutaneous SCC.

Basal cell carcinoma
BCCs arise from the basal keratinocytes.Typically slow-growing, they rarely invade or metastasise.This is the most common of all forms of cancer, with an annual incidence of 283 per 100,000 population in England. 22The most common subtype of BCC is nodular -this has a pearly, shiny, rolled edge and arborising telangiectasia (Fig. 4).Ulceration may occur, usually observed as central yellow or red crust, or reported by patients as a recurring, non-healing sore.Other subtypes include superficial, morphoeic (scar-like) (Fig. 6) and infiltrative -these may lack the pearly edge but often feature telangiectasia. 23Pigmented BCCs also occur, sometimes presenting as potential melanomas. 24The main reason to diagnose and treat these slower-growing, less invasive tumours is to avoid ulceration and disfigurement, as a large BCC can require significant reconstruction after removal.

Squamous cell carcinoma
Compared to the BCCs, the SCCs are less common (85 per 100,000 population per year) but have more potential for local invasion and metastasis. 22They can be diverse in appearance and less stereotypical in appearance than the BCCs.As such, any nodule on the skin that is indurated (a hardened base), or tender to palpation should raise suspicion.SCCs can be keratin-bearing, producing a central scaly surface or even large horn-like projections.They can also ulcerate and thus be mistaken for BCCs, particularly if they are poorly differentiated and lack the ability to produce keratin.Organ transplant recipients are at raised risk of SCC and skin surveillance is recommended for all such patients.Incidental detection is welcome, particularly if a new lesion arises between check-ups. 5n in situ form of SCC is Bowen's disease.This has a red, thickened appearance and typically occurs on the shin, but can also be seen on the head and neck.
A notable differential for SCC is the keratoacanthoma, a keratin-bearing fleshy nodule which appears and grows rapidly and will spontaneously regress.Its appearance is of a 'volcano-like' profile with significant central keratin plug.This physical description also fits a well-differentiated SCC, so such lesions should be treated as such in most cases with prompt referral for dermatological assessment.

Vascular lesions
Haemangiomas are benign tumours arising from vascular endothelium.A common form, increasing with age, is of small, cherryred macules or papules which blanch under pressure, known as cherry haemangiomas or Campbell de Morgan spots.We mention haemangiomas here as larger lesions can take on a dark red to black hue and thus appear pigmented (Fig. 7).A variant of note is the lobular capillary haemangioma, or pyogenic granuloma (Fig. 8).This is a nodular vascular tumour, prone to bleeding with minimal provocation, often with a pedunculated form.They can be seen at sites of trauma on the head and neck and often arise in young

Acting on suspected skin cancer
GDPs discovering lesions suspicious for cancer should advise GMP assessment.The GMP will then decide whether onward referral is warranted, using for example the two-week-wait skin cancer referral pathway.The NHS produces guidance to support this for pigmented lesions, using the weighted seven-point checklist (Table 1). 25,26For nonmelanoma skin cancers, all suspected SCCs should be referred, but BCCs are generally referred on a routine basis, reflecting their indolent growth rate and low risk of invasion.Exception is made for a facial lesions or large lesions.
The GDP, in correspondence with the GMP, should aim to include the history of the lesion and clinical appearance, preferably supplemented with clinical photographs.They should also establish follow-up with the patient concerned as a safety net in case of delays in assessment.The patient should be kept informed throughout these discussions, of what has been asked and what to expect.

Conclusion
Skin cancer is common, arises often on the head and neck and GDPs are well-placed to identify them.Patient history, including risk factors along with physical findings, can provide the basis for suspicion of BCC, SCC or MM.Pigmented lesions raise suspicion of melanoma, but also include benign entities, such as naevi and seborrhoeic keratoses.
Non-pigmented lesions may be SCC or BCC but may be actinic keratosis.Vascular lesions tend to appear red to purple but are generally benign.We advocate referral -or advice to self-refer -unless the lesion is confidently identified as benign, but inclusion of clinical detail in the referral can help colleagues in general medical practice and hospital specialties, who will always be grateful for the chance to intervene early.

2 Seborrhoeic keratosis Feature Concerning Reassuring Asymmetry
Asymmetry of shape, asymmetric distribution of colour or texture Round profile, uniformity